Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice
Copyright policy )Area identity shifts in the early cerebral cortex of Emx2−/− mutant mice
The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene Emx2 in the developing cortex has prompted suggestions that it is critical in this context. We tested this hypothesis using Emx2 -/- mice. We found that the normal spectrum of cortical areal identities was encoded in these mutants, but areas with caudal-medial identities were reduced and those with anterior-lateral identities were relatively expanded in the cortex.
- University College London United Kingdom
- Vita-Salute San Raffaele University Italy
- International School for Advanced Studies Italy
Cerebral Cortex, Homeodomain Proteins, Mice, Knockout, Afferent Pathways, Brain Mapping, Cell Adhesion Molecules, Neuronal, Mice, Transgenic, Neocortex, GPI-Linked Proteins, beta-Galactosidase, Receptor, Nerve Growth Factor, Mice, Nerve Fibers, Animals, Cues, Transcription Factors
Cerebral Cortex, Homeodomain Proteins, Mice, Knockout, Afferent Pathways, Brain Mapping, Cell Adhesion Molecules, Neuronal, Mice, Transgenic, Neocortex, GPI-Linked Proteins, beta-Galactosidase, Receptor, Nerve Growth Factor, Mice, Nerve Fibers, Animals, Cues, Transcription Factors
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