Murine Chromosomal Location of Four Class III POU Transcription Factors
pmid: 8276397
Murine Chromosomal Location of Four Class III POU Transcription Factors
A family of mouse genes encoding class III POU transcription factors consists of four members: Oct-6, Brn-2, Brn-1, and Brn-4. In accordance with mouse nomenclature, these loci have been designated Otf-6, Otf-7, Otf-8, and Otf-9, respectively. While the four genes share a highly conserved class III POU domain, the remaining regions are considerably diverged from each other. The POU domains of these transcription factors recognize the octamer-motif sequence and possess a similar DNA-binding specificity. Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome.
- National Institute of Health Pakistan
- Nagoya University Japan
- University of Tokyo Japan
DNA-Binding Proteins, Male, Mice, Inbred C57BL, Mice, POU Domain Factors, Animals, Chromosome Mapping, Female, Transcription Factors
DNA-Binding Proteins, Male, Mice, Inbred C57BL, Mice, POU Domain Factors, Animals, Chromosome Mapping, Female, Transcription Factors
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