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Biosynthesis of polyketides by two type III polyketide synthases from Aloe barbadensis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 03 Dec 2019Publisher:Informa UK LimitedJournal:Journal of Asian Natural Products Research, volume 22, pages 434-443 (issn: 1028-6020, eissn: 1477-2213,

Authors: Dawei Chen; Jungui Dai; Jimei Liu; Yu-Yu Liu; Song-yang Sui; Lin Yang; Ridao Chen; +2 Authors

doi: 10.1080/10286020.2019.1674287 , 10.6084/m9.figshare.11309447.v1 , 10.6084/m9.figshare.11309447

pmid: 31791147

Biosynthesis of polyketides by two type III polyketide synthases from Aloe barbadensis

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Abstract

Various bioactive polyketides have been found in Aloe barbadensis. However, the polyketide synthases (PKSs), which participate in biosynthesis of polyketides in A. barbadensis remain unknown. In this study, two type III PKSs (AbPKS1 and AbPKS2) were identified from A. barbadensis. AbPKS1 and AbPKS2 were able to utilize malonyl-CoA to yield heptaketides (TW93a and aloesone) and octaketides (SEK4 and SEK4b), respectively. AbPKS1 also exhibited catalytic promiscuity in recognizing CoA thioesters of aromatics to produce unusual polyketides. What Is more, a whole cell biocatalysis system with the capability of producing 26.4 mg/L of SEK4/SEK4b and 2.1 mg/L of aloesone was successfully established.

Related Organizations

PEKING UNION MEDICAL COLLEGE
China (People's Republic of)
Chinese Academy of Medical Sciences & Peking Union Medical College
China (People's Republic of)
Minzu University of China
China (People's Republic of)

Keywords

Molecular Structure, Polyketides, Aloe, Polyketide Synthases, Acyltransferases

3 Research products, page 1 of 1

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Biosynthesis of polyketides by two type III polyketide synthases from Aloe barbadensis

Biosynthesis of polyketides by two type III polyketide synthases from Aloe barbadensis

3 Research products, page 1 of 1

Multiple Beneficial Effects of Aloesone from Aloe vera on LPS-Induced RAW264.7 Cells, Including the Inhibition of Oxidative Stress, Inflammation, M1 Polarization, and Apoptosis

Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria

Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models