Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Copyright policy )Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins, account for 70% of the released bactericidal peptide activity. Gram-negative bacteria, Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit cryptdin secretion. Live fungi and protozoa, however, do not stimulate degranulation. Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.
- University of Mary United States
- Washington University in St. Louis United States
- University of California, Irvine United States
Lipopolysaccharides, Mice, Knockout, Salmonella typhimurium, Paneth Cells, Staphylococcus aureus, Teichoic Acids, Mice, Lipid A, Matrix Metalloproteinase 7, Intestine, Small, Escherichia coli, Animals, Protein Precursors
Lipopolysaccharides, Mice, Knockout, Salmonella typhimurium, Paneth Cells, Staphylococcus aureus, Teichoic Acids, Mice, Lipid A, Matrix Metalloproteinase 7, Intestine, Small, Escherichia coli, Animals, Protein Precursors
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