Molecular Cloning and Chromosomal Mapping of the Human Homologue of MYB Binding Protein (P160) 1A (MYBBP1A) to 17p13.3
Copyright policy )Molecular Cloning and Chromosomal Mapping of the Human Homologue of MYB Binding Protein (P160) 1A (MYBBP1A) to 17p13.3
We have previously isolated and characterized murine MYB binding protein (p160) 1a, a protein that specifically interacts with the leucine zipper motif within the negative regulatory domain of the c-Myb proto-oncoprotein. We now describe the molecular cloning of the human MYBBP1A cDNA and chromosomal localization to 17p13.3 by fluorescence in situ hybridization analysis. Given the likely presence of a tumor suppressor gene (or genes) within this region of chromosome 17, the position of MYBBP1A was further mapped by radiation hybrid analysis and was found to lie between markers D17S1828 and D17S938. A P1 artificial chromosome clone containing the 5' region of MYBBP1A was isolated and indicates a physical linkage between MYBBP1A and the 15-lipoxygenase gene (ALOX15). A novel, polymorphic (CA)(25) dinucleotide repeat was also isolated from this PAC and may serve as a useful marker for MYBBP1A and this region of chromosome 17.
- Cleveland Clinic United States
- Boston Children's Hospital United States
- Women's and Children's Hospital Australia
- Hanson Institute Australia
- University of Queensland Australia
Nucleocytoplasmic Transport Proteins, Tumor-suppressor Gene, 17p, Sequence Homology, Dna-binding, Region, Northern, Cloning, Molecular, Dinucleotide Repeats, In Situ Hybridization, In Situ Hybridization, Fluorescence, Genetics & Heredity, Blotting, Nuclear Proteins, RNA-Binding Proteins, Physical Chromosome Mapping, DNA-Binding Proteins, Amino Acid, Organ Specificity, Sequence Analysis, Human, Genetic Markers, Locus, Molecular Sequence Data, Chromosomes, Fluorescence, Deletion, Suggests, Terminology as Topic, Humans, Amino Acid Sequence, Alleles, P53, Transactivation, Base Sequence, Sequence Homology, Amino Acid, Pair 17, Molecular, DNA, Sequence Analysis, DNA, Blotting, Northern, Biotechnology & Applied Microbiology, C-myb, Carrier Proteins, Transcription Factors, Cloning, Chromosomes, Human, Pair 17
Nucleocytoplasmic Transport Proteins, Tumor-suppressor Gene, 17p, Sequence Homology, Dna-binding, Region, Northern, Cloning, Molecular, Dinucleotide Repeats, In Situ Hybridization, In Situ Hybridization, Fluorescence, Genetics & Heredity, Blotting, Nuclear Proteins, RNA-Binding Proteins, Physical Chromosome Mapping, DNA-Binding Proteins, Amino Acid, Organ Specificity, Sequence Analysis, Human, Genetic Markers, Locus, Molecular Sequence Data, Chromosomes, Fluorescence, Deletion, Suggests, Terminology as Topic, Humans, Amino Acid Sequence, Alleles, P53, Transactivation, Base Sequence, Sequence Homology, Amino Acid, Pair 17, Molecular, DNA, Sequence Analysis, DNA, Blotting, Northern, Biotechnology & Applied Microbiology, C-myb, Carrier Proteins, Transcription Factors, Cloning, Chromosomes, Human, Pair 17
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