Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy
Copyright policy )Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy
In this study, we aimed to investigate the possible association between SLC2A1 26177A/G polymorphism and diabetic retinopathy (DR) in Malaysian patients with type 2 diabetes.Genomic DNA was extracted from 211 Malaysian type 2 diabetic patients (100 without retinopathy [DNR], 111 with retinopathy) and 165 healthy controls. A high resolution melting assay developed in this study was used to detect SLC2A1 26177A/G polymorphism followed by statistical analysis.A statistically significant difference in 26177G minor allele frequency between healthy controls (19.7 %) and total patient group (26.1 %) (p0.05).This is the first study which shows that SLC2A1 26177G allele is associated with type 2 diabetes in Malaysian population but not with DR.
- Universiti Malaysia Terengganu Malaysia
- University of Malaya Malaysia
Male, Glucose Transporter Type 1, Heterozygote, Diabetic Retinopathy, Genotyping Techniques, Homozygote, Malaysia, R Medicine, Middle Aged, Nucleic Acid Denaturation, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Diabetes Mellitus, Type 2, Gene Frequency, 616, Humans, Female, Alleles, Genetic Association Studies, Aged
Male, Glucose Transporter Type 1, Heterozygote, Diabetic Retinopathy, Genotyping Techniques, Homozygote, Malaysia, R Medicine, Middle Aged, Nucleic Acid Denaturation, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Diabetes Mellitus, Type 2, Gene Frequency, 616, Humans, Female, Alleles, Genetic Association Studies, Aged
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