Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex
Copyright policy )Pyramidal Neurons Are Generated from Oligodendroglial Progenitor Cells in Adult Piriform Cortex
Previous studies have shown that oligodendroglial progenitor cells (OPCs) can give rise to neuronsin vitroand in perinatal cerebral cortexin vivo. We now report that OPCs in adult murine piriform cortex express low levels of doublecortin, a marker for migratory and immature neurons. Additionally, these OPCs express Sox2, a neural stem cell marker, and Pax6, a transcription factor characteristic of progenitors for cortical glutamatergic neurons. Genetic fate-mapping by means of an inducible Cre–LoxP recombination system proved that these OPCs differentiate into pyramidal glutamatergic neurons in piriform cortex. Several lines of evidence indicated that these newly formed neurons became functionally integrated into the cortical neuronal network. Our data suggest that NG2+/PDGFRα+proteolipid protein promoter-expressing progenitors generate pyramidal glutamatergic neurons within normal adult piriform cortex.
- University of California, Davis United States
- Yale University United States
Cerebral Cortex, Doublecortin Domain Proteins, Homeodomain Proteins, Antineoplastic Agents, Hormonal, Green Fluorescent Proteins, Cell Count, Cell Differentiation, Mice, Transgenic, Nerve Tissue Proteins, Drug Administration Schedule, Mice, Inbred C57BL, Adult Stem Cells, Mice, Bromodeoxyuridine, Gene Expression Regulation, Animals, Antigens, Eye Proteins, Myelin Proteolipid Protein, Microtubule-Associated Proteins
Cerebral Cortex, Doublecortin Domain Proteins, Homeodomain Proteins, Antineoplastic Agents, Hormonal, Green Fluorescent Proteins, Cell Count, Cell Differentiation, Mice, Transgenic, Nerve Tissue Proteins, Drug Administration Schedule, Mice, Inbred C57BL, Adult Stem Cells, Mice, Bromodeoxyuridine, Gene Expression Regulation, Animals, Antigens, Eye Proteins, Myelin Proteolipid Protein, Microtubule-Associated Proteins
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