RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states
Copyright policy )RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states
SignificanceNeuropathic pain is a complex disorder, characterized by affective and sensory symptoms. Efficient treatment of this condition should target both pain-modulating pathways and mood/affect networks. We show that tricyclic antidepressants (TCAs), which modulate spinal pain processing, also act in the brain reward center to alleviate allodynia and depression-like behaviors. We reveal how one key protein of nucleus accumbens (NAc)-specific signaling affects several molecules/pathways with emerging roles in antinociceptive and antidepressant mechanisms. Our study provides information about the cellular adaptations induced by TCAs in the NAc and novel targets for pain treatment.
- Icahn School of Medicine at Mount Sinai United States
- University of Crete Greece
- McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA United States
- Massachusetts Institute of Technology United States
Male, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Gene Expression, Adaptation, Physiological, Antidepressive Agents, Corpus Striatum, Nucleus Accumbens, Mice, Inbred C57BL, Gene Ontology, Treatment Outcome, Hyperalgesia, Animals, Neuralgia, Female, Gene Regulatory Networks, RGS Proteins
Male, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Gene Expression, Adaptation, Physiological, Antidepressive Agents, Corpus Striatum, Nucleus Accumbens, Mice, Inbred C57BL, Gene Ontology, Treatment Outcome, Hyperalgesia, Animals, Neuralgia, Female, Gene Regulatory Networks, RGS Proteins
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