Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene
Copyright policy )Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene
Acyl-CoA synthetases (ACSs) play an essential role in fatty acid metabolism. ACS3 is an arachidonate-preferring enzyme expressed in a wide range of human tissues including brain, heart, placenta, prostate, skeletal muscle, testis and thymus. As an initial step to understanding the transcriptional regulation of the human ACS3 gene, we analyzed the genomic organization and transcription units of the human ACS3 gene. Sequence analysis of genomic clones demonstrates that the human ACS3 gene spans at least 80.6 kb and contains 17 exons. The human ACS3 gene was mapped between the sequence-tagged site markers D2S360 and WI-21901. Sequence inspection of the 5'-flanking region revealed potential DNA elements including CCAAT, AP-1, Oct-1, GATAs, SRY, CdxA, Nkx-2.5, c-Myb, HSF2, NF-AT, AP-2, NF-Y, and p300. A minimal promoter region required for the expression of the human ACS3 gene in melanoma G361 cells was determined.
- Chonnam National University Korea (Republic of)
- Tohoku University Japan
- Kurume University Japan
Male, Base Sequence, 5' Flanking Region, Molecular Sequence Data, Chromosome Mapping, Gene Expression, HL-60 Cells, DNA, Exons, Introns, Genes, Chromosomes, Human, Pair 2, Coenzyme A Ligases, Humans, Female, Amino Acid Sequence, K562 Cells, Luciferases, Promoter Regions, Genetic, HeLa Cells
Male, Base Sequence, 5' Flanking Region, Molecular Sequence Data, Chromosome Mapping, Gene Expression, HL-60 Cells, DNA, Exons, Introns, Genes, Chromosomes, Human, Pair 2, Coenzyme A Ligases, Humans, Female, Amino Acid Sequence, K562 Cells, Luciferases, Promoter Regions, Genetic, HeLa Cells
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