Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity
Copyright policy )Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity
Key Points Foxp3 expression is increased by DNMT inhibitors and may have potential utility in efforts to develop Foxp3+ Tregs for cellular therapy. Dnmt1 deletion impairs Treg function and results in lethal autoimmunity, such that use of Dnmt inhibitors may warrant careful consideration.
- University of Pennsylvania United States
- Children's Hospital of Philadelphia United States
DNA (Cytosine-5-)-Methyltransferase 1, Mice, Knockout, Mice, Inbred BALB C, Autoimmunity, Forkhead Transcription Factors, Genetic Therapy, Immunotherapy, Adoptive, T-Lymphocytes, Regulatory, Gene Expression Regulation, Enzymologic, Autoimmune Diseases, Mice, Inbred C57BL, Mice, Animals, Cell Lineage, DNA (Cytosine-5-)-Methyltransferases, Cells, Cultured, Gene Deletion
DNA (Cytosine-5-)-Methyltransferase 1, Mice, Knockout, Mice, Inbred BALB C, Autoimmunity, Forkhead Transcription Factors, Genetic Therapy, Immunotherapy, Adoptive, T-Lymphocytes, Regulatory, Gene Expression Regulation, Enzymologic, Autoimmune Diseases, Mice, Inbred C57BL, Mice, Animals, Cell Lineage, DNA (Cytosine-5-)-Methyltransferases, Cells, Cultured, Gene Deletion
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