PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
Copyright policy )PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
AbstractElucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play an essential role in normal hematopoiesis. More recently, somatic missense PTPN11 gain-of-function mutations have been detected in leukemias and rarely in solid tumors, and have been found to induce aberrant hyperactivation of the Ras-Erk pathway. This progress represents another milestone in the leukemia/cancer research field and provides a fresh view on the molecular mechanisms underlying cell transformation.
- Indiana University United States
- Indiana University School of Medicine United States
- Xiamen University China (People's Republic of)
- Sanford Burnham Prebys Medical Discovery Institute United States
FACIO-CUTANEOUS SYNDROME, Noonan Syndrome, Intracellular Signaling Peptides and Proteins, Protein Tyrosine Phosphatase, Non-Receptor Type 11, ACUTE MYELOID-LEUKEMIA, COLONY-STIMULATING FACTOR, Proto-Oncogene Mas, Hematopoiesis, HEMATOPOIETIC-CELL DEVELOPMENT, Proto-Oncogene Proteins, Mutation, MYELODYSPLASTIC SYNDROMES, MYELOGENO, Humans, CAUSE NOONAN-SYNDROME, JUVENILE MYELOMONOCYTIC LEUKEMIA, Protein Tyrosine Phosphatases, GROWTH-FACTOR RECEPTOR, MYELOPROLIFERATIVE DISORDER, Signal Transduction
FACIO-CUTANEOUS SYNDROME, Noonan Syndrome, Intracellular Signaling Peptides and Proteins, Protein Tyrosine Phosphatase, Non-Receptor Type 11, ACUTE MYELOID-LEUKEMIA, COLONY-STIMULATING FACTOR, Proto-Oncogene Mas, Hematopoiesis, HEMATOPOIETIC-CELL DEVELOPMENT, Proto-Oncogene Proteins, Mutation, MYELODYSPLASTIC SYNDROMES, MYELOGENO, Humans, CAUSE NOONAN-SYNDROME, JUVENILE MYELOMONOCYTIC LEUKEMIA, Protein Tyrosine Phosphatases, GROWTH-FACTOR RECEPTOR, MYELOPROLIFERATIVE DISORDER, Signal Transduction
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