Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain
Copyright policy )Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain
Dbl-family guanine nucleotide exchange factors (Dbl-GEFs) act as activators of Rho-like small G proteins such as Rac1, Cdc42 and RhoA. Recently, some GEFs have been suggested to play important roles in the development of the nervous system. Here, we report a comprehensive expression profile analysis of 20 Dbl-GEFs that have yet to be well investigated. Northern analyses of murine mRNAs from brains of E13, E17, P7 and adult mice revealed expression of 18 out of 20 GEFs in some or all stages. In addition, we found that three human GEFs were highly expressed in the brain. Examination of the spatial expression patterns of five GEFs in embryos or neonatal brain by in situ hybridization revealed distinct patterns for each GEF. Our study reveals the dynamic and coordinated expression profiles of the Dbl-GEFs and provides a basic framework for understanding the function of GEFs in neural development.
- Kyoto University Japan
- Kazusa DNA Research Institute Japan
Gene Expression Profiling, Molecular Sequence Data, Brain, Gene Expression Regulation, Developmental, Mice, Multigene Family, Animals, Guanine Nucleotide Exchange Factors, Humans, Amino Acid Sequence, Sequence Alignment, In Situ Hybridization
Gene Expression Profiling, Molecular Sequence Data, Brain, Gene Expression Regulation, Developmental, Mice, Multigene Family, Animals, Guanine Nucleotide Exchange Factors, Humans, Amino Acid Sequence, Sequence Alignment, In Situ Hybridization
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).23 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!