Inhibiting Interleukin-18 Production Through the Mitogen-Activated Protein Kinase Pathway, A Potential Role of Corticotropin-Releasing Hormone in Chronic Plaque Psoriasis
Copyright policy )Inhibiting Interleukin-18 Production Through the Mitogen-Activated Protein Kinase Pathway, A Potential Role of Corticotropin-Releasing Hormone in Chronic Plaque Psoriasis
Corticotropin-releasing hormone (CRH) and CRH receptors (CRH-Rs) are expressed in the skin; CRH-R1 is the predominant receptor. Whether the CRH/CRH-R1 system plays a role in psoriasis has not yet been assessed. Immunohistochemistry, real-time RT-PCR, ELISA assay, and Western blot analysis were used to investigate the expression of CRH/CRH-R1 in patients with chronic plaque psoriasis and that of IL-18 in CRH-treated HaCaT cells. CRH and CRH-R1 were downregulated in patients with chronic plaque psoriasis. In vitro, CRH attenuated the expression of IL-18 by a mitogen-activated protein kinase signaling pathway through CRH-R1 in HaCaT cells. Thus, an aberrant cutaneous CRH/CRH-R1 system exists in lesions from chronic plaque psoriasis which might play a role in psoriasis and offers further evidence for the study of CRH in the skin.
- Shandong Women’s University China (People's Republic of)
Adult, Male, Corticotropin-Releasing Hormone, MAP Kinase Signaling System, Interleukin-18, Down-Regulation, CRF Receptor, Type 1, Middle Aged, Receptors, Corticotropin-Releasing Hormone, Cell Line, Young Adult, Humans, Psoriasis, Female, Mitogen-Activated Protein Kinases, Skin
Adult, Male, Corticotropin-Releasing Hormone, MAP Kinase Signaling System, Interleukin-18, Down-Regulation, CRF Receptor, Type 1, Middle Aged, Receptors, Corticotropin-Releasing Hormone, Cell Line, Young Adult, Humans, Psoriasis, Female, Mitogen-Activated Protein Kinases, Skin
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