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Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Mar 2016Publisher:Elsevier BVJournal:Data in Brief, volume 6, pages 715-721 (issn: 2352-3409,

Authors: Blake Borgeson; Snejana Stoilova; Sadhna Phanse; W. Brent Derry; Mihail Sarov; Olga Kagan; Kyle Chessman; +23 Authors

doi: 10.1016/j.dib.2015.11.062

pmid: 26870755

pmc: PMC4738005

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

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Abstract

Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].

Related Organizations

Hospital for Sick Children
Canada
Harvard University
United States
Max Planck Institute of Neurobiology
Germany
University of Toronto, Department of Molecular Genetics
Canada
Max Planck Society
Germany

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Keywords

Q1-390, Science (General), Computer applications to medicine. Medical informatics, R858-859.7, Data Article

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