Notch in T-ALL: new players in a complex disease
Copyright policy )Notch in T-ALL: new players in a complex disease
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of thymocytes affecting preferentially children and adolescents. The disease is heterogeneous and characterized by a large set of chromosomal and genetic alterations that deregulate the growth of maturing thymocytes. The identification of activating point mutations in NOTCH1 in more then 50% of all T-ALL cases highlights the NOTCH1 cascade as a central player of T-ALL pathogenesis. In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling.
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
Thymocytes, Adolescent, Gene Expression Regulation, Leukemic, T-Lymphocytes, Cell Differentiation, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Translocation, Genetic, Neoplasm Proteins, Genes, T-Cell Receptor, Mice, MicroRNAs, Species Specificity, Animals, Humans, Point Mutation, Gene Regulatory Networks, Molecular Targeted Therapy, Receptor, Notch1, Child, Signal Transduction
Thymocytes, Adolescent, Gene Expression Regulation, Leukemic, T-Lymphocytes, Cell Differentiation, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Translocation, Genetic, Neoplasm Proteins, Genes, T-Cell Receptor, Mice, MicroRNAs, Species Specificity, Animals, Humans, Point Mutation, Gene Regulatory Networks, Molecular Targeted Therapy, Receptor, Notch1, Child, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).58 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!