The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells
Copyright policy )The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells
AbstractThis study aimed to synthesize new thioderivative chalcones and analyze their impact on the NF-κB, STAT3, EGFR and Nrf2 signaling pathways in colorectal cancer cells. Among the studied compounds, derivatives 4 and 5 decreased the activation of NF-κB and the expression of the target gene COX-2. In the case of STAT3, we observed the inhibition of activation of this signaling pathway after influencing derivative 4. Increased activation of the Nrf2 signaling pathway was demonstrated for derivatives 5 and 7 in DLD-1 and HCT116 cells. The results of this study indicated that new chalcone derivatives, especially compounds 4, 5, and—to some degree—7, possess potential applications in the prevention of colorectal cancer.
STAT3 Transcription Factor, NF-E2-Related Factor 2, Science, Q, R, NF-kappa B, Article, Chalcone, Chalcones, Medicine, Humans, Colorectal Neoplasms, Signal Transduction
STAT3 Transcription Factor, NF-E2-Related Factor 2, Science, Q, R, NF-kappa B, Article, Chalcone, Chalcones, Medicine, Humans, Colorectal Neoplasms, Signal Transduction
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