Differential regulation of the zinc finger genesKrox-20 andKrox-24 (Egr-1) suggests antagonistic roles in Schwann cells
Copyright policy )Differential regulation of the zinc finger genesKrox-20 andKrox-24 (Egr-1) suggests antagonistic roles in Schwann cells
Krox-20 and Krox-24 (Egr-1) encode closely related zinc finger transcription factors, which interact with the same DNA target sequences. Krox-20 is required for myelination in the peripheral nervous system. Using lacZ knock-in mutant mouse lines as well as immunohistochemical analyses, we have studied the expression of Krox-20 and Krox-24 in the Schwann cell lineage during normal development and following nerve lesion in the mouse and in human neuropathies. During embryogenesis, the two genes are expressed in a successive and mutually exclusive manner, Krox-24 being restricted to Schwann cell precursors and Krox-20 to mature Schwann cells. At birth, Krox-24 is reactivated and the two genes are coexpressed. In the adult, Krox-20 is expressed in myelinating cells, while Krox-24 is restricted to nonmyelinating cells. Following nerve lesion, Krox-24 is strongly induced in Schwann cells, reinforcing the link between its expression and the nonmyelinating and/or proliferative state, whereas Krox-20 is downregulated. These data are consistent with Krox-20 and Krox-24 playing antagonistic roles during the development of the Schwann cell lineage. In particular, their balance of expression might participate in the choice between myelinating and nonmyelinating pathways.
- Goa University India
- École Normale Supérieure France
- Inserm France
- University of Genoa Italy
- French Institute of Health and Medical Research France
Stem Cells, Gene Expression Regulation, Developmental, Zinc Fingers, Embryo, Mammalian, Sciatic Nerve, Immediate-Early Proteins, DNA-Binding Proteins, Mice, Animals, DNA-Binding Proteins; biosynthesis, Early Growth Response Protein 1, Early Growth Response Protein 2, Embryo; Mammalian, Gene Expression Regulation; Developmental, Humans, Immediate-Early Proteins, Mice, Myelin Sheath; metabolism, Nervous System Diseases; metabolism, Schwann Cells; metabolism, Sciatic Nerve; embryology/metabolism, Stem Cells; metabolism, Sural Nerve; metabolism, Transcription Factors; biosynthesis, Zinc Fingers, Sural Nerve, Animals, Humans, Schwann Cells, Nervous System Diseases, Early Growth Response Protein 2, Myelin Sheath, Early Growth Response Protein 1, Transcription Factors
Stem Cells, Gene Expression Regulation, Developmental, Zinc Fingers, Embryo, Mammalian, Sciatic Nerve, Immediate-Early Proteins, DNA-Binding Proteins, Mice, Animals, DNA-Binding Proteins; biosynthesis, Early Growth Response Protein 1, Early Growth Response Protein 2, Embryo; Mammalian, Gene Expression Regulation; Developmental, Humans, Immediate-Early Proteins, Mice, Myelin Sheath; metabolism, Nervous System Diseases; metabolism, Schwann Cells; metabolism, Sciatic Nerve; embryology/metabolism, Stem Cells; metabolism, Sural Nerve; metabolism, Transcription Factors; biosynthesis, Zinc Fingers, Sural Nerve, Animals, Humans, Schwann Cells, Nervous System Diseases, Early Growth Response Protein 2, Myelin Sheath, Early Growth Response Protein 1, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).109 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!