Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
Copyright policy )Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma
Significance Human lymphomas and leukemias are characterized by molecular and structural alterations of transcription factors (TFs). The identification of such deregulated TFs is therefore central to the understanding of lymphomagenesis. We addressed this question in classical Hodgkin lymphoma (HL), a common B-cell–derived malignancy that is one of the most prominent examples for complex patterns of deregulated TFs including the activation of NF-κB or AP-1 and a profound deregulation of lineage-specific TFs. We found that IRF5 together with NF-κB induces a number of HL characteristic features in non-Hodgkin cells, such as expression of cytokines and chemokines or AP-1 activation. Our work exemplifies how the global lymphoma type-specific characterization of TF activities can improve the understanding of tumor biology.
- University of Leeds United Kingdom
- Vaccine & Gene Therapy Institute of Florida United States
- Pathologisches Institut Germany
- Philipps-University of Marburg Germany
- Polish Academy of Sciences Poland
Inflammation, B-Lymphocytes, Lymphoma, Chemotaxis, Gene Expression Profiling, Lymphoma, Non-Hodgkin, Amino Acid Motifs, Medizin, Hodgkin Disease, Chromatin, Gene Expression Regulation, Neoplastic, Mice, Cell Line, Tumor, Interferon Regulatory Factors, Leukocytes, Mononuclear, Animals, Cytokines, Deoxyribonuclease I, Humans, Cell Lineage, Chemokines
Inflammation, B-Lymphocytes, Lymphoma, Chemotaxis, Gene Expression Profiling, Lymphoma, Non-Hodgkin, Amino Acid Motifs, Medizin, Hodgkin Disease, Chromatin, Gene Expression Regulation, Neoplastic, Mice, Cell Line, Tumor, Interferon Regulatory Factors, Leukocytes, Mononuclear, Animals, Cytokines, Deoxyribonuclease I, Humans, Cell Lineage, Chemokines
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