Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis
Copyright policy )Tumor suppressor Menin acts as a corepressor of LXRα to inhibit hepatic lipogenesis
Menin, encoded by the MEN1 gene, was initially identified as a tumor suppressor for endocrine neoplasia. Our previous report showed that Menin enhances PPARα transactivity preventing triglyceride accumulation in the liver. Here, we further explore the role of Menin in liver steatosis. Transient transfection assays demonstrate that Menin inhibits the transcriptional activity of nuclear receptor liver X receptor α (LXRα). Accordingly, Menin overexpression results in reduced expression of LXRα target genes, such as lipogenic enzymes including SREBP‐1c, FASN and SCD‐1. Co‐immunoprecipitation assays revealed physical interaction between Menin and LXRα. Collectively, our data suggest that Menin acts as a novel corepressor of LXRα and functions as a negative regulator of hepatic lipogenesis.
- Second Military Medical University China (People's Republic of)
- Changhai Hospital China (People's Republic of)
Blotting, Western, Primary Cell Culture, Gene Expression, Proto-Oncogene Proteins, Animals, Humans, Immunoprecipitation, Cells, Cultured, Liver X Receptors, Adipogenesis, Lipogenesis, Liver Neoplasms, Menin, Hep G2 Cells, Orphan Nuclear Receptors, Mice, Inbred C57BL, HEK293 Cells, Liver, Hepatocytes, Hepatic lipogenesis, RNA Interference, Liver X receptor α, Protein Binding
Blotting, Western, Primary Cell Culture, Gene Expression, Proto-Oncogene Proteins, Animals, Humans, Immunoprecipitation, Cells, Cultured, Liver X Receptors, Adipogenesis, Lipogenesis, Liver Neoplasms, Menin, Hep G2 Cells, Orphan Nuclear Receptors, Mice, Inbred C57BL, HEK293 Cells, Liver, Hepatocytes, Hepatic lipogenesis, RNA Interference, Liver X receptor α, Protein Binding
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