A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache
Copyright policy )A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache
Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.
- University of Turin Italy
Adult, Male, Receptors, Neuropeptide, Genotype, Cluster Headache, Middle Aged, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled, Cohort Studies, Gene Frequency, Orexin Receptors, Case-Control Studies, Humans, Female, hypocretin; orexin; HCRTR2 gene; cluster headache
Adult, Male, Receptors, Neuropeptide, Genotype, Cluster Headache, Middle Aged, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled, Cohort Studies, Gene Frequency, Orexin Receptors, Case-Control Studies, Humans, Female, hypocretin; orexin; HCRTR2 gene; cluster headache
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).114 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!