Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA–like structural element in the ribosomal decoding center
Copyright policy )Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA–like structural element in the ribosomal decoding center
Significance Ribosomes decode genetic information encoded in mRNAs to synthesize cellular proteins. Initiation of translation is a key step, during which the ORF coding for a protein gets properly positioned on the ribosome with the AUG start codon and its cognate tRNA located in the ribosomal peptidyl site. Here, we report molecular structures of a eukaryotic ribosome complexed with viral mRNA, which uncover an unusual mechanism of initiation. The structures reveal that viral mRNAs carrying an intergenic RNA structure known as the internal ribosome entry site (IRES) initiate translation by binding a tRNA-mRNA–like element in the aminoacyl site of the ribosome. A structural mechanism of how viral mRNAs with intergenic IRESs hijack host ribosomes is proposed.
- University of Massachusetts Medical School United States
- Janelia Research Campus United States
- Brandeis University United States
- Howard Hughes Medical Institute United States
Biophysics, Genetics and Genomics, Therapeutics, Picornaviridae, Biochemistry, Cell and Developmental Biology, Open Reading Frames, RNA, Transfer, and Structural Biology, Nucleic Acid Conformation, RNA, Viral, RNA, Messenger, Peptide Chain Initiation, Translational, Ribosomes
Biophysics, Genetics and Genomics, Therapeutics, Picornaviridae, Biochemistry, Cell and Developmental Biology, Open Reading Frames, RNA, Transfer, and Structural Biology, Nucleic Acid Conformation, RNA, Viral, RNA, Messenger, Peptide Chain Initiation, Translational, Ribosomes
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