unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans
Copyright policy )unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans
unc-3 encodes the Caenorhabditis elegans ortholog of the Olf-1/Early B cell factor family of transcription factors, which in vertebrates regulate development and differentiation of B lymphocytes, adipocytes, and cells of the nervous system. unc-3 mutants are uncoordinated in locomotion. Here we show that unc-3 represses a VC-like motor neuron program in the VA and VB motor neurons, which in wild-type animals control backwards and forwards locomotion, respectively. We identify a physical interaction between UNC-3 and the C2H2 zinc finger transcription factor PAG-3, the mammalian homologs of which are coexpressed in olfactory epithelium and hematopoietic cells. Our data explain the locomotory defects of unc-3 mutants and suggest that interactions between unc-3 and pag-3 orthologs in other species may be functionally important.
- Johns Hopkins Medicine United States
- Johns Hopkins University School of Medicine United States
- The University of Texas Southwestern Medical Center United States
- Regeneron (United States) United States
Embryo, Nonmammalian, Gfi-1, Cell Count, Cell Line, pag-3, olf-1, Animals, Humans, Immunoprecipitation, Cell Lineage, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Molecular Biology, Motor Neurons, Cell Differentiation, Cell Biology, Exons, Ebf-1, DNA-Binding Proteins, Motor neuron fate, Organ Specificity, unc-3, Mutation, Dimerization, Biomarkers, Developmental Biology, Protein Binding, Transcription Factors
Embryo, Nonmammalian, Gfi-1, Cell Count, Cell Line, pag-3, olf-1, Animals, Humans, Immunoprecipitation, Cell Lineage, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Molecular Biology, Motor Neurons, Cell Differentiation, Cell Biology, Exons, Ebf-1, DNA-Binding Proteins, Motor neuron fate, Organ Specificity, unc-3, Mutation, Dimerization, Biomarkers, Developmental Biology, Protein Binding, Transcription Factors
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