Histone chaperones regulate histone exchange during transcription
Copyright policy )Histone chaperones regulate histone exchange during transcription
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway, using a dual histone expression system. The results showed that the exchange of H3/H4 normally occurs during transcription by the histone chaperones. Both Asf1 and HIR are important for histone deposition but have a different effect on histone exchange. While Asf1 mediated incorporation of external H3/H4 and renewal of pre-existing histones, HIR opposed it. The balance of two opposing activities might be an important mechanism for determining current chromatin states.
- Sungkyul University Korea (Republic of)
- Sungkyunkwan University Korea (Republic of)
- New Generation University College Ethiopia
- Seoul National University Korea (Republic of)
Saccharomyces cerevisiae Proteins, Transcription, Genetic, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae, Nucleosomes, Fungal Proteins, Histones, Repressor Proteins, Mutation, Gene Silencing, RNA Polymerase II, Gene Deletion, Molecular Chaperones
Saccharomyces cerevisiae Proteins, Transcription, Genetic, Nuclear Proteins, Cell Cycle Proteins, Saccharomyces cerevisiae, Nucleosomes, Fungal Proteins, Histones, Repressor Proteins, Mutation, Gene Silencing, RNA Polymerase II, Gene Deletion, Molecular Chaperones
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