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Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2019 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 10, pages 4,069-4,076 (issn: 2041-6520, eissn: 2041-6539, Copyright policy )Funded by:WT | unidentified, UKRI | Conformational selection ...
Authors: James A. H. Gilburt; Paul Girvan; Julian Blagg; Liming Ying; Charlotte A. Dodson;

doi: 10.1039/c8sc03669a

pmid: 31015948

pmc: PMC6461105

handle: 10044/1/68971

Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation

Abstract

Activation loop phosphorylation changes the position of equilibrium between DFG-in-like and DFG-out-like conformations but not the conformational preference of inhibitors.

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Keywords

/dk/atira/pure/subjectarea/asjc/1600/1606, 570, Chemistry, /dk/atira/pure/subjectarea/asjc/1600/1605, Organic Chemistry, Biophysics, Physical and Theoretical Chemistry, 540, /dk/atira/pure/subjectarea/asjc/1300/1304

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 6
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Top 10%
Average
Average
Green
gold