In Vitro Properties of MEDI-4212, a Human Anti-IgE Antibody for the Treatment of Allergic Asthma.
Sarah Oakley; Mats Carlsson; Per-Olof Fredrik Eriksson; K von Wachenfeldt; H. Ekdahl; E. S. Cohen; Sofia Persdotter; +11 Authors
Sarah Oakley; Mats Carlsson; Per-Olof Fredrik Eriksson; K von Wachenfeldt; H. Ekdahl; E. S. Cohen; Sofia Persdotter; S Klakamp; U Alkner; Phillip Monk; I de Mendez; Anthony J. Coyle; Ian A. Anderson; S OBrian; Dorothy A. Sims; Claire Dobson; M Azimi; Chris Lloyd;
In Vitro Properties of MEDI-4212, a Human Anti-IgE Antibody for the Treatment of Allergic Asthma.
HuFceRI transfected RBL or LAD2 cells were incubated with IgE ± MEDI4212. Bound IgE was cross-linked using a commercial anti-IgE and cell activation detected using calcium signalling or β-hexosaminidase release. Effect of MEDI4212 on IgE/CD23 interaction was assessed by incubation of IL-4 stimulated IM9 cells with IgE ± MEDI4212 and bound IgE detected by flow cytometry. Effects on IgE production in human B cells (differentiated with APC + IL-4, ± MEDI4212) was evaluated by flow cytometry. Serum free-IgE was measured using ELISA.
- Southampton General Hospital United Kingdom
- University Hospital Southampton NHS Foundation Trust United Kingdom
- MedImmune United States
- ASTRAZENECA UK LIMITED United Kingdom
- AbbVie Inc. United States
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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