On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms
Copyright policy )On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms
Wiring the Retina Starburst amacrine cells in the retina detect motion by responding to light going on or off. L. O. Sun et al. ( 10.1126/science.1241974 ) analyzed how the cellular circuits develop in the mouse retina to form the basis of motion detection. Expression patterns of semaphorin 6A and its receptor plexin A2 defined the shape and reactivity of the starburst amacrine cells. Semaphorin 6A expression was restricted to particular cells, generating two classes of starburst amacrine cells with distinct morphologies and opposing functions.
- University of California, Berkeley United States
- University of California, San Francisco United States
- Johns Hopkins Medicine United States
- Helen Wills Neuroscience Institute United States
- Johns Hopkins University School of Medicine United States
General Science & Technology, Motion Perception, Nerve Tissue Proteins, Receptors, Cell Surface, Dendrites, Semaphorins, Mice, Mutant Strains, Retina, Mutant Strains, Mice, Motion, Amacrine Cells, Receptors, Cell Surface, Animals, Eye Disease and Disorders of Vision, Signal Transduction
General Science & Technology, Motion Perception, Nerve Tissue Proteins, Receptors, Cell Surface, Dendrites, Semaphorins, Mice, Mutant Strains, Retina, Mutant Strains, Mice, Motion, Amacrine Cells, Receptors, Cell Surface, Animals, Eye Disease and Disorders of Vision, Signal Transduction
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