Arg972 insulin receptor substrate‐1 polymorphism and risk and severity of rheumatoid arthritis
Copyright policy )Arg972 insulin receptor substrate‐1 polymorphism and risk and severity of rheumatoid arthritis
AbstractAimTo explore the association between the Arg972 insulin receptor substrate (IRS)‐1 polymorphism (rs1801278) and the risk and disease activity/severity of rheumatoid arthritis (RA).MethodWe genotyped the Arg972 IRS‐1 polymorphism in 871 pairs of age‐, sex‐, body mass index‐, residence area‐ and current smoking status‐matched RA patients and controls. We assessed RA severity using the disease activity score of 28 joints (DAS28).ResultsThe AA (homozygous Arg972 IRS‐1) and GA (heterozygous Arg972 IRS‐1) genotypes were significantly associated with high risk of RA with or without adjustment for comorbidities (P < 0.001). The A allele was significantly associated with high risk of RA (P < 0.001). The AA genotype was significantly associated with high/severe RA activity (P < 0.001), while the GG genotype (wild type IRS‐1) had protective effects.ConclusionThe Arg972 IRS‐1 polymorphism is associated with increased risk and disease activity/severity of RA, and therefore may be a potential prognostic factor for RA. This study adds novel insights into the pathogenesis of RA.
- Central South University China (People's Republic of)
Adult, Male, Heterozygote, Polymorphism, Genetic, Homozygote, Middle Aged, Protective Factors, Severity of Illness Index, Arthritis, Rheumatoid, Phenotype, Risk Factors, Case-Control Studies, Insulin Receptor Substrate Proteins, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
Adult, Male, Heterozygote, Polymorphism, Genetic, Homozygote, Middle Aged, Protective Factors, Severity of Illness Index, Arthritis, Rheumatoid, Phenotype, Risk Factors, Case-Control Studies, Insulin Receptor Substrate Proteins, Humans, Female, Genetic Predisposition to Disease, Genetic Association Studies
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