Additional file 7 of R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

appsOther research productkeyboard_double_arrow_right Image 01 Jan 2021Publisher:figshareFunded by:NIH | Alabama Neuroscience Blue..., NIH | Novel Treatment of NF-1 A..., NIH | Therapeutic Targeting of ... +8 projects

Authors: Weber, Shannon M.; Brossier, Nicole M.; Prechtl, Amanda; Barnes, Stephen; Wilson, Landon S.; Brosius, Stephanie N.; Longo, Jody Fromm; +1 Authors

doi: 10.6084/m9.figshare.16633115 , 10.6084/m9.figshare.16633115.v1

Additional file 7 of R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

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Abstract

Additional file 7. Figure S6 Signalling effectors affected by DN R-Ras induction. (A) Expression of induced DN R-Ras ST88-14 MPNST cells compared to control, either uninduced DN R-Ras ST88-14 MPNST cells or induced GFP ST88-14 MPNST cells. R-Ras and R-Ras2 immunoblotting show the presence of the HA-tagged DN R-Ras as a thick band above the endogenous Ras/Ras2 levels. Immunoblots comparing the effect of DN R-Ras expression on cofilin, RhoA, pERK1/2, total ERK1/2, pAKT and total AKT are also shown. (B) Raf-1 RBD pulldown assays demonstrating the effect of DN R-Ras expression on the activation of R-Ras proteins.

16 Research products, page 1 of 2

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