Identification of a set of genes with developmentally down-regulated expression in the mouse brain
Copyright policy )Identification of a set of genes with developmentally down-regulated expression in the mouse brain
Using a subtraction cloning approach, we have isolated a set of cDNA clones from mouse neural precursor cells whose respective mRNA levels are down-regulated during the development of mouse brain. Single stranded DNA prepared from neuronal precursor cell cDNA library in lambda Zap vector was subtracted with poly (A)+ RNA prepared from postnatal and adult mouse brain to obtain several clones which show developmental down-regulation of expression. Their patterns of expression indicate that these genes may play important roles during the embryonic development and differentiation of central nervous system.
- RIKEN Japan
- Cancer Institute India
Aging, Base Sequence, Molecular Sequence Data, Brain, Glyceraldehyde-3-Phosphate Dehydrogenases, Gestational Age, DNA, Blotting, Northern, Embryo, Mammalian, Embryonic and Fetal Development, Mice, Gene Expression Regulation, Genes, Oligodeoxyribonucleotides, Animals, RNA, RNA, Messenger, Cloning, Molecular, Poly A, Gene Library
Aging, Base Sequence, Molecular Sequence Data, Brain, Glyceraldehyde-3-Phosphate Dehydrogenases, Gestational Age, DNA, Blotting, Northern, Embryo, Mammalian, Embryonic and Fetal Development, Mice, Gene Expression Regulation, Genes, Oligodeoxyribonucleotides, Animals, RNA, RNA, Messenger, Cloning, Molecular, Poly A, Gene Library
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