Class I HLA‐A*7401 Is Associated with Protection from HIV‐1 Acquisition and Disease Progression in Mbeya, Tanzania
Copyright policy )Class I HLA‐A*7401 Is Associated with Protection from HIV‐1 Acquisition and Disease Progression in Mbeya, Tanzania
Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4(+) cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.
- Ludwig-Maximilians-Universität München Germany
- Henry M. Jackson Foundation United States
- Walter Reed Army Institute of Research United States
Male, Genotype, HLA-A Antigens, Black People, HIV Infections, Tanzania, CD4 Lymphocyte Count, Cohort Studies, Gene Frequency, Disease Progression, HIV-1, Humans, Female, Genetic Predisposition to Disease, Alleles
Male, Genotype, HLA-A Antigens, Black People, HIV Infections, Tanzania, CD4 Lymphocyte Count, Cohort Studies, Gene Frequency, Disease Progression, HIV-1, Humans, Female, Genetic Predisposition to Disease, Alleles
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!