Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
Copyright policy )Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
SNARE proteins function at the center of membrane fusion reactions by forming complexes with each other via their coiled-coil domains. Several SNAREs have N-terminal domains (NTDs) that precede the coiled-coil domain and have critical functions in regulating the fusion cascade. This review will highlight recent findings on NTDs of syntaxins, the longin domain of VAMP proteins and SNAP-23/25 homologues in yeast. Biochemical and genetic experiments as well as the resolution of several NMR and crystal structures of SNARE NTDs shed light on their diverse function.
- Univerity of Heidelberg Germany
- Biochemie Zentrum Heidelberg Germany
- University Heildelberg Germany
- Heidelberg University Germany
Models, Molecular, N-terminal domain, Vam7, Vesicular Transport Proteins, Membrane Proteins, Cell Biology, Membrane Fusion, Protein Structure, Tertiary, Structure-Activity Relationship, SNARE, Animals, Humans, Syntaxin, SNARE Proteins, Longin, SM protein, Molecular Biology
Models, Molecular, N-terminal domain, Vam7, Vesicular Transport Proteins, Membrane Proteins, Cell Biology, Membrane Fusion, Protein Structure, Tertiary, Structure-Activity Relationship, SNARE, Animals, Humans, Syntaxin, SNARE Proteins, Longin, SM protein, Molecular Biology
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