Identification and characterization of mouse PSF1-binding protein, SLD5
Copyright policy )Identification and characterization of mouse PSF1-binding protein, SLD5
Although most somatic cells cannot proliferate, immature cells proliferate continuously to produce mature cells. Recently, we cloned mouse PSF1 from a hematopoietic stem cell specific cDNA library and reported that PSF1 is indispensable for the proliferation of immature cells. To identify the PSF1-binding protein, we used the yeast two-hybrid system with PSF1 as bait, and identified and cloned SLD5. SLD5 interacted with a central region of PSF1. Tissue distribution of SLD5 was quite similar to that of PSF1. When overexpressed, SLD5 protein was co-localized with PSF1. These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations.
Binding Sites, Molecular Sequence Data, Mice, Organ Specificity, Protein Interaction Mapping, NIH 3T3 Cells, Animals, ATP-Binding Cassette Transporters, Tissue Distribution, Amino Acid Sequence, ATP Binding Cassette Transporter, Subfamily B, Member 2, Carrier Proteins, Protein Binding
Binding Sites, Molecular Sequence Data, Mice, Organ Specificity, Protein Interaction Mapping, NIH 3T3 Cells, Animals, ATP-Binding Cassette Transporters, Tissue Distribution, Amino Acid Sequence, ATP Binding Cassette Transporter, Subfamily B, Member 2, Carrier Proteins, Protein Binding
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