Relationship between Germline MC1R Variants and BRAF-Mutant Melanoma in a North Carolina Population-Based Study
Copyright policy )Relationship between Germline MC1R Variants and BRAF-Mutant Melanoma in a North Carolina Population-Based Study
A few previous studies have examined the relationship between germline melanocortin-1 receptor (MC1R) status and somatic BRAF mutations in melanoma. Two publications reported strong associations in three independent populations (two from Italy and one from San Francisco) (Fargnoli et al., 2008; Landi et al., 2006), while a more recent publication found no association in an Australian population-based study (Hacker et al., 2009). We report our finding of no significant association between MC1R status and BRAF-mutant melanomas in a population-based study of malignant melanoma in North Carolina.
- University of New Mexico United States
- University of North Carolina at Chapel Hill United States
- UNC Lineberger Comprehensive Cancer Center United States
- University of Pennsylvania United States
- Memorial Sloan Kettering Cancer Center United States
Proto-Oncogene Proteins B-raf, Skin Neoplasms, Genetic Variation, Cell Biology, Dermatology, Biochemistry, Risk Factors, North Carolina, Humans, Molecular Biology, Melanoma, Receptor, Melanocortin, Type 1, Germ-Line Mutation
Proto-Oncogene Proteins B-raf, Skin Neoplasms, Genetic Variation, Cell Biology, Dermatology, Biochemistry, Risk Factors, North Carolina, Humans, Molecular Biology, Melanoma, Receptor, Melanocortin, Type 1, Germ-Line Mutation
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