CD4+CD3− Cells Induce Peyer's Patch Development
Copyright policy )CD4+CD3− Cells Induce Peyer's Patch Development
CD4+CD3- cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or alpha4beta1 integrin-mediated adhesion. CXCR5-/- mice have CD4+CD3- cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. Blocking of beta1 integrin or VCAM-1, the ligand of alpha4beta1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation.
- Helmholtz Association of German Research Centres Germany
- Ludwig Institute for Cancer Research United States
- Ludwig Institute for Cancer Research - Lausanne Branch Switzerland
- Max Delbrück Center for Molecular Medicine Germany
- ETH Zurich Switzerland
CD4-Positive T-Lymphocytes, Receptors, CXCR5, CD3 Complex, Immunology, Integrin alpha4beta1, Mice, Peyer's Patches, Cell Adhesion, Morphogenesis, Immunology and Allergy, Animals, Receptors, Cytokine, Mice, Knockout, Immunologic Deficiency Syndromes, Models, Immunological, Adoptive Transfer, Chemokine CXCL13, Mice, Inbred C57BL, Infectious Diseases, Radiation Chimera, Receptors, Chemokine, Chemokines, CXC, Signal Transduction
CD4-Positive T-Lymphocytes, Receptors, CXCR5, CD3 Complex, Immunology, Integrin alpha4beta1, Mice, Peyer's Patches, Cell Adhesion, Morphogenesis, Immunology and Allergy, Animals, Receptors, Cytokine, Mice, Knockout, Immunologic Deficiency Syndromes, Models, Immunological, Adoptive Transfer, Chemokine CXCL13, Mice, Inbred C57BL, Infectious Diseases, Radiation Chimera, Receptors, Chemokine, Chemokines, CXC, Signal Transduction
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