descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2011 English Publisher:Elsevier BVJournal:Journal of Investigative Dermatology, volume 131, pages 285-287 (issn: 0022-202X,

Authors: Borkowski, Andrew W.; Gallo, Richard L.;

doi: 10.1038/jid.2010.360

pmid: 21228809

pmc: PMC3121688

The Coordinated Response of the Physical and Antimicrobial Peptide Barriers of the Skin

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Abstract

Antimicrobial peptides (AMPs) are an essential and multifunctional element for immune defense of the skin during infection and injury. In this issue, Ahrens et al. characterize the response of β-defensins, a class of AMPs, following acute and chronic challenges to the permeability barrier of the skin. Their findings suggest that the antimicrobial and permeability barriers of the skin are closely linked.

Related Organizations

University of California, San Diego
United States
University of California, San Diego
United States
VA San Diego Healthcare System
United States

Keywords

Keratinocytes, Cell Membrane Permeability, beta-Defensins, Cell Biology, Dermatology, Biochemistry, Dermatitis, Atopic, Mice, Skin Physiological Phenomena, Models, Animal, Rosacea, Animals, Humans, Psoriasis, Molecular Biology, Antimicrobial Cationic Peptides, Skin

12 Research products, page 1 of 2

Mechanical and Metabolic Injury to the Skin Barrier Leads to Increased Expression of Murine β-Defensin-1, -3, and -14
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