The Retromer Protein VPS29 Links Cell Polarity and Organ Initiation in Plants
Copyright policy )The Retromer Protein VPS29 Links Cell Polarity and Organ Initiation in Plants
A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell by polarized auxin efflux carriers, termed PIN-FORMED (PIN) proteins. Here we report that the Arabidopsis ortholog of the yeast and mammalian vacuolar protein sorting 29 (VPS29), a member of the retromer complex, mediates the formation of new axes of development. Furthermore, we show that VPS29 is required for endosome homeostasis, PIN protein cycling, and dynamic PIN1 repolarization during development. We propose a model that links VPS29 function, PIN1 polarity, and organ initiation in plants.
Genotype, PROTEINS, Recombinant Fusion Proteins, Meristem, Arabidopsis, DEVBIO, Endosomes, Guanine Nucleotide Exchange Factors, Cell Proliferation, Indoleacetic Acids, Biochemistry, Genetics and Molecular Biology(all), Arabidopsis Proteins, Cell Polarity, Membrane Transport Proteins, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Cell Differentiation, Plants, Genetically Modified, Protein Transport, Phenotype, Multiprotein Complexes, Mutation, CELLBIO, Carrier Proteins, Cotyledon, Signal Transduction
Genotype, PROTEINS, Recombinant Fusion Proteins, Meristem, Arabidopsis, DEVBIO, Endosomes, Guanine Nucleotide Exchange Factors, Cell Proliferation, Indoleacetic Acids, Biochemistry, Genetics and Molecular Biology(all), Arabidopsis Proteins, Cell Polarity, Membrane Transport Proteins, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Cell Differentiation, Plants, Genetically Modified, Protein Transport, Phenotype, Multiprotein Complexes, Mutation, CELLBIO, Carrier Proteins, Cotyledon, Signal Transduction
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