Promotion of Met-tRNA i Met Binding to Ribosomes by yIF2, a Bacterial IF2 Homolog in Yeast
Copyright policy )Promotion of Met-tRNA i Met Binding to Ribosomes by yIF2, a Bacterial IF2 Homolog in Yeast
Delivery of the initiator methionine transfer RNA (Met-tRNA i Met ) to the ribosome is a key step in the initiation of protein synthesis. Previous results have indicated that this step is catalyzed by the structurally dissimilar translation factors in prokaryotes and eukaryotes—initiation factor 2 (IF2) and eukaryotic initiation factor 2 (eIF2), respectively. A bacterial IF2 homolog has been identified in both eukaryotes and archaea. By using a combination of molecular genetic and biochemical studies, the Saccharomyces cerevisiae IF2 homolog is shown to function in general translation initiation by promoting Met-tRNA i Met binding to ribosomes. Thus, the mechanism of protein synthesis in eukaryotes and prokaryotes is more similar than was previously realized.
- National Institutes of Health United States
- National Institute of Health Pakistan
- Case Western Reserve University United States
Cytoplasm, RNA, Transfer, Met, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Eukaryotic Initiation Factor-2, Codon, Initiator, Saccharomyces cerevisiae, Prokaryotic Initiation Factor-2, DNA-Binding Proteins, Fungal Proteins, Peptide Initiation Factors, Protein Biosynthesis, Peptide Chain Initiation, Translational, Protein Kinases, Ribosomes
Cytoplasm, RNA, Transfer, Met, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Eukaryotic Initiation Factor-2, Codon, Initiator, Saccharomyces cerevisiae, Prokaryotic Initiation Factor-2, DNA-Binding Proteins, Fungal Proteins, Peptide Initiation Factors, Protein Biosynthesis, Peptide Chain Initiation, Translational, Protein Kinases, Ribosomes
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