Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells
Copyright policy )Monoclonal antibody to parathyroid hormone-related protein induces differentiation and apoptosis of chondrosarcoma cells
We investigated the effects of treatment with anti-parathyroid hormone-related protein (1-34) monoclonal murine antibody (anti-PTHrP MoAb) on apoptosis and the differentiation of chondrosarcoma HTB-94 cells. Treatment with anti-PTHrP MoAb accelerated apoptosis of HTB-94 cells in a dose-dependent manner, and anti-PTHrP MoAb also promoted the chondrogenic differentiation of HTB-94 cells. The induction of apoptosis by anti-PTHrP MoAb via imbalance of Bcl-2/Bax ratio and activation of caspase-3 may provide a mechanistic explanation for its potential antitumor effects. Our results suggest the possibility that anti-PTHrP MoAb may be beneficial as a new treatment for chondrosarcoma.
- Osaka University Japan
- Chugai Pharmaceutical Co. Japan
Caspase 3, Reverse Transcriptase Polymerase Chain Reaction, Chondrosarcoma, Parathyroid Hormone-Related Protein, Antibodies, Monoclonal, Apoptosis, Bone Neoplasms, Cell Differentiation, Peptide Fragments, Immunoenzyme Techniques, Proto-Oncogene Proteins c-bcl-2, Caspases, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Collagen Type II, Cell Division, Collagen Type X, DNA Primers, bcl-2-Associated X Protein
Caspase 3, Reverse Transcriptase Polymerase Chain Reaction, Chondrosarcoma, Parathyroid Hormone-Related Protein, Antibodies, Monoclonal, Apoptosis, Bone Neoplasms, Cell Differentiation, Peptide Fragments, Immunoenzyme Techniques, Proto-Oncogene Proteins c-bcl-2, Caspases, Proto-Oncogene Proteins, Tumor Cells, Cultured, Humans, Collagen Type II, Cell Division, Collagen Type X, DNA Primers, bcl-2-Associated X Protein
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