Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population
Copyright policy )Association analysis of the GDNF gene with methamphetamine use disorder in a Japanese population
Methamphetamine (MAP) dependence is a highly heritable and aberrant dopaminergic signaling that has been implicated in the disease. Glial cell line-derived neurotrophic factor (GDNF), which plays an important role in the survival of dopaminergic neurons, may be involved in this disorder. In this study, we examined the association between GDNF and MAP dependence using a Japanese population-based sample. We selected eight single nucleotide polymorphisms (SNPs) in the GDNF locus for the association analysis. When patients with MAP dependence were divided into two subgroups consisting of multi-substance and MAP-only users, we detected a significant association between these two groups and the tagging SNP, rs2910704 (after Bonferroni's correction; allele P=0.034). Thus, GDNF is likely to be related to the severity of MAP use in the Japanese population.
- Meijo University Japan
- Nagoya University Japan
- Seiwa Hospital Japan
- Okayama University Japan
- Icahn School of Medicine at Mount Sinai United States
Male, Genotype, Dopamine, Amphetamine-Related Disorders, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Asian People, Gene Frequency, Japan, Humans, Female, Genetic Predisposition to Disease, Glial Cell Line-Derived Neurotrophic Factor, Alleles, Sequence Tagged Sites, Signal Transduction
Male, Genotype, Dopamine, Amphetamine-Related Disorders, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Asian People, Gene Frequency, Japan, Humans, Female, Genetic Predisposition to Disease, Glial Cell Line-Derived Neurotrophic Factor, Alleles, Sequence Tagged Sites, Signal Transduction
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