Stuck in the middle: Rac, adhesion, and cytokinesis
Copyright policy )Stuck in the middle: Rac, adhesion, and cytokinesis
Rho family small GTPases (Rac, RhoA, and Cdc42) function at the core of cytokinesis, the physical division of one cell into two. In this issue, Bastos et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201204107) identify a new role for Rac inhibition: to release cell adhesion at the division plane and allow efficient constriction of the contractile ring. They show that the GTPase-activating protein, CYK4, suppresses equatorial cell substrate adhesion by inhibiting Rac and therefore its effectors ARFGEF7 and PAK1/2.
- Columbia University United States
- King’s University United States
rac1 GTP-Binding Protein, p21-Activated Kinases, GTPase-Activating Proteins, Reviews, Guanine Nucleotide Exchange Factors, Humans, Rho Guanine Nucleotide Exchange Factors, Cytokinesis
rac1 GTP-Binding Protein, p21-Activated Kinases, GTPase-Activating Proteins, Reviews, Guanine Nucleotide Exchange Factors, Humans, Rho Guanine Nucleotide Exchange Factors, Cytokinesis
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