Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system
Copyright policy )Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system
Previously, we reported a zebrafish iroquois gene, ziro3, and its expression during early embryogenesis (Mech. Dev. 87 (1999) 165). In the present study, we have isolated two novel zebrafish iroquois genes, ziro1 and ziro5, homologs of mouse Irx1 and mouse Irx5, respectively. The expression of both genes is initiated in dorsal neuroectoderm and mesoderm during gastrulation. Later, their expression appears in the central nervous system (CNS), excluding the telencephalon and most of the diencephalon. ziro1 expression is complementary to that of ziro3 in the notochord and later in the gut. In contrast, ziro5 expression mostly overlaps with that of ziro3. Interestingly, all three iroquois zebrafish genes are expressed in the notochord while only Irx3 is active in the mouse notochord. Their expression in later stages of embryogenesis was also compared.
- National University of Singapore Singapore
- National University of Singapore Libraries Singapore
Central Nervous System, Telencephalon, 570, Embryology, DNA, Complementary, Time Factors, Molecular Sequence Data, Notochord, Midbrain, Mice, Genome mapping, Rhombomere, Homeobox, Animals, Amino Acid Sequence, Diencephalon, Placode, In Situ Hybridization, Zebrafish, Homeodomain Proteins, Models, Genetic, Sequence Homology, Amino Acid, Embryos, Chordo-neural hinge, Zebrafish Proteins, Hindbrain, Floor plate, Developmental Biology, Transcription Factors
Central Nervous System, Telencephalon, 570, Embryology, DNA, Complementary, Time Factors, Molecular Sequence Data, Notochord, Midbrain, Mice, Genome mapping, Rhombomere, Homeobox, Animals, Amino Acid Sequence, Diencephalon, Placode, In Situ Hybridization, Zebrafish, Homeodomain Proteins, Models, Genetic, Sequence Homology, Amino Acid, Embryos, Chordo-neural hinge, Zebrafish Proteins, Hindbrain, Floor plate, Developmental Biology, Transcription Factors
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