Cvt19 Is a Receptor for the Cytoplasm-to-Vacuole Targeting Pathway
Copyright policy )Cvt19 Is a Receptor for the Cytoplasm-to-Vacuole Targeting Pathway
Cvt19 is specifically required for the transport of resident vacuolar hydrolases that utilize the cytoplasm-to-vacuole targeting (Cvt) pathway. Autophagy (Apg) and pexophagy, processes that use the majority of the same protein components as the Cvt pathway, do not require Cvt19. Cvt19GFP is localized to punctate structures on or near the vacuole surface. Cvt19 is a peripheral membrane protein that binds to the precursor form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole with prAPI. These results suggest that Cvt19 is a receptor protein for prAPI that allows for the selective transport of this protein by both the Cvt and Apg pathways.
- University of Michigan–Ann Arbor United States
- University of California, Davis United States
- University of Michigan–Flint United States
Cytoplasm, Saccharomyces cerevisiae Proteins, Membrane Proteins, Cell Biology, Saccharomyces cerevisiae, Aminopeptidases, Fungal Proteins, Mutation, Vacuoles, Autophagy, Protein Precursors, Carrier Proteins, Molecular Biology, Plasmids, Protein Binding
Cytoplasm, Saccharomyces cerevisiae Proteins, Membrane Proteins, Cell Biology, Saccharomyces cerevisiae, Aminopeptidases, Fungal Proteins, Mutation, Vacuoles, Autophagy, Protein Precursors, Carrier Proteins, Molecular Biology, Plasmids, Protein Binding
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