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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Prostaglandins Leuko...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Prostaglandins Leukotrienes and Essential Fatty Acids
Article . 1992 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Prostaglandins Leukotrienes and Essential Fatty Acids
Article . 1993
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/095...
Article
Data sources: Microsoft Academic Graph
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Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1992 English Publisher:Elsevier BVJournal:Prostaglandins, Leukotrienes and Essential Fatty Acids, volume 47, pages 105-110 (issn: 0952-3278, Copyright policy )
Authors: J W, Schmidley; J, Dadson; R S, Iyer; R G, Salomon;

doi: 10.1016/0952-3278(92)90145-9

pmid: 1461920

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

Abstract

The hypothesis that the accumulation of prostaglandin (PG)E2 during reperfusion of severely ischemic tissue contributes to a breakdown in the blood-brain barrier (BBB) was expanded to include a parallel role for levuglandins(LGs), gamma-ketoaldehydes produced by rearrangement of PGH2. LGE2 was shown to be more potent than PGE2 in causing breakdown of the BBB when injected intrahemispherically. Brain tissue necrosis was clearly evident with total doses of levuglandin as low as 100 nmole.

Related Organizations
Keywords

Male, Prostaglandins E, Brain, Brain Edema, Dinoprostone, Rats, Necrosis, Body Water, Blood-Brain Barrier, Animals, Female, Evans Blue

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 41
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
41
Average
Top 10%
Average
Related to Research communities
Neuroscience