The expression and modulation of CEACAM1 and tumor cell transformation
Copyright policy )The expression and modulation of CEACAM1 and tumor cell transformation
Background. In this review, we focus our discussion on one class of carcinoembryonic antigen- related cell adhesion molecules, Carcinoembryonic antigen-related cell adhesion molecules 1 (CEACAM1). This has been observed in several malignant transformations to be subjected to complex mechanisms of modulation and dysregulation. Aims. Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity in vivo, and therefore, this adhesion molecule has been regarded as a tumor suppressor. In contrast, de novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small Cell Lung Carcinoma (NSCLC) as well as bladder, prostate, thyroid, breast, colon and gastric carcinomas. Discussion.We report and discuss the most significant findings confirming at immunohistochemical and clinical level the correlation between poor prognosis and expression of CEACAM1 on the cell surface of tumors.
Inhibitor of Differentiation Protein 1, Lung Neoplasms, alterata regolazione, cancro, NSCLC, Antigens, CD, Antigens, Neoplasm, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, melanoma, Biomarkers, Tumor, Humans, Protein Isoforms, Molecular Targeted Therapy, Neoplasm Metastasis, CEACAM1, Melanoma, Carcinoma, prognosi infausta, Antibodies, Monoclonal, Prognosis, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Colonic Neoplasms, Public aspects of medicine, RA1-1270, Cell Adhesion Molecules
Inhibitor of Differentiation Protein 1, Lung Neoplasms, alterata regolazione, cancro, NSCLC, Antigens, CD, Antigens, Neoplasm, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, melanoma, Biomarkers, Tumor, Humans, Protein Isoforms, Molecular Targeted Therapy, Neoplasm Metastasis, CEACAM1, Melanoma, Carcinoma, prognosi infausta, Antibodies, Monoclonal, Prognosis, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, Colonic Neoplasms, Public aspects of medicine, RA1-1270, Cell Adhesion Molecules
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