Combined Effect of CYP2B6 and NAT2 Genotype on Plasma Efavirenz Exposure During Rifampin-based Antituberculosis Therapy in the STRIDE Study
Copyright policy )Combined Effect of CYP2B6 and NAT2 Genotype on Plasma Efavirenz Exposure During Rifampin-based Antituberculosis Therapy in the STRIDE Study
In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.
- Vanderbilt University United States
- Oswaldo Cruz Foundation Brazil
- University of Cape Town South Africa
- San Francisco General Hospital United States
- Harvard University United States
Cyclopropanes, Male, Genotype, Arylamine N-Acetyltransferase, 590, Antitubercular Agents, 610, Clinical sciences, HIV Infections, Medical and Health Sciences, Microbiology, South Africa, Peru, Genetics, Humans, Tuberculosis, Uganda, Biomedical and Clinical Sciences, efavirenz, Pharmacology and Pharmaceutical Sciences, Biological Sciences, Benzoxazines, Cytochrome P-450 CYP2B6, Good Health and Well Being, tuberculosis, Pharmacogenetics, Alkynes, Adult AIDS Clinical Trials Group A5221 and A5243 Study Teams, pharmacogenetic, HIV/AIDS, Female, Rifampin, rifampin
Cyclopropanes, Male, Genotype, Arylamine N-Acetyltransferase, 590, Antitubercular Agents, 610, Clinical sciences, HIV Infections, Medical and Health Sciences, Microbiology, South Africa, Peru, Genetics, Humans, Tuberculosis, Uganda, Biomedical and Clinical Sciences, efavirenz, Pharmacology and Pharmaceutical Sciences, Biological Sciences, Benzoxazines, Cytochrome P-450 CYP2B6, Good Health and Well Being, tuberculosis, Pharmacogenetics, Alkynes, Adult AIDS Clinical Trials Group A5221 and A5243 Study Teams, pharmacogenetic, HIV/AIDS, Female, Rifampin, rifampin
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