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Bral1: “Superglue” for the extracellular matrix in the brain white matter

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2012 English Publisher:Elsevier BVJournal:The International Journal of Biochemistry & Cell Biology, volume 44, pages 596-599 (issn: 1357-2725,

Authors: Eva Syková; Lydia Vargova; Michal Cicanic;

doi: 10.1016/j.biocel.2012.01.009

pmid: 22300985

Bral1: “Superglue” for the extracellular matrix in the brain white matter

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Abstract

Bral1 is a link protein that stabilizes the binding between lecticans and hyaluronic acid and thus maintains the extracellular matrix assembly in the CNS. Bral1 is specifically located in the white matter around the nodes of Ranvier. Recent studies suggest its function in promoting saltatory neural conduction. This article reviews the current knowledge about the structure, expression and function of this link protein.

Related Organizations

Charles University
Czech Republic

Keywords

Gene Expression Regulation, Animals, Brain, Humans, Nerve Tissue Proteins, Extracellular Matrix

5 Research products, page 1 of 1

Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.
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Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.
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Bral1: “Superglue” for the extracellular matrix in the brain white matter

Bral1: “Superglue” for the extracellular matrix in the brain white matter

5 Research products, page 1 of 1

Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.

Bral1, a Brain-Specific Link Protein, Colocalizing with the Versican V2 Isoform at the Nodes of Ranvier in Developing and Adult Mouse Central Nervous Systems

Neurocan contributes to the molecular heterogeneity of the perinodal ECM

Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.

Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS