About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESR1) in breast cancer
Copyright policy )About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESR1) in breast cancer
In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1.
- Université Libre de Bruxelles Belgium
- Institut Jules Bordet Belgium
Hepatocyte Nuclear Factor 3-alpha, X-Box Binding Protein 1, XBP-1, Oestrogen receptor-α, Molecular Sequence Data, Breast Neoplasms, Regulatory Factor X Transcription Factors, GATA3 Transcription Factor, HNF-3α, GATA-3, Breast cancer, Humans, Promoter Regions, Genetic, TFF1, Base Sequence, Tumor Suppressor Proteins, Estrogen Receptor alpha, Nuclear Proteins, Proteins, Sciences bio-médicales et agricoles, Cancérologie, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Trans-Activators, Female, Trefoil Factor-1, Transcription Factors
Hepatocyte Nuclear Factor 3-alpha, X-Box Binding Protein 1, XBP-1, Oestrogen receptor-α, Molecular Sequence Data, Breast Neoplasms, Regulatory Factor X Transcription Factors, GATA3 Transcription Factor, HNF-3α, GATA-3, Breast cancer, Humans, Promoter Regions, Genetic, TFF1, Base Sequence, Tumor Suppressor Proteins, Estrogen Receptor alpha, Nuclear Proteins, Proteins, Sciences bio-médicales et agricoles, Cancérologie, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Trans-Activators, Female, Trefoil Factor-1, Transcription Factors
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