Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence
Copyright policy )Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence
To relate paraoxonase (PON1) activity to survival time and short term death in breast cancer recurrence.PON1 activity was measured by its rate of hydrolysis of two different substrates, paraoxon (PON) and phenylacetate (ARE) in 50 patients with recurrence of breast cancer. Results were compared between patients surviving more than one year after the analysis (22) and those who died within one year (28).In a logistic regression analysis, ARE was negatively associated with early death (OR=0.10 [0.02-0.58], p=0.0109). PON did not reach significance (OR=0.43 [0.17-1.11], p=0.0826). In a multiple logistic regression analysis model, ARE was independently associated with early death (OR=0.12 [0.02-0.98], p=0.0476), besides interval time between diagnosis and recurrence (OR=0.54 [0.27-1.07], p=0.0781) and undernutrition (OR=3.95 [0.81-19.19], p=0.0883).Paraoxonase is a potential marker of survival in patients with breast cancer recurrence.
- Inserm France
- National Research Institute for Agriculture, Food and Environment France
- Université de Rennes 1 France
- University of Nantes France
- University of Rennes France
Adult, [SDV]Life Sciences [q-bio], ARYLESTERASE, 610, Breast Neoplasms, Paraoxon, Breast cancer, Biomarkers, Tumor, Humans, METAANALYSIS, POLYMORPHISMS, Enzyme Assays, Phenylacetates, Aryldialkylphosphatase, Hydrolysis, Carcinoma, Ductal, Breast, Middle Aged, Survival Analysis, [SDV] Life Sciences [q-bio], Logistic Models, Oxidative stress, Paraoxonase, Female, Neoplasm Recurrence, Local, SERUM PARAOXONASE
Adult, [SDV]Life Sciences [q-bio], ARYLESTERASE, 610, Breast Neoplasms, Paraoxon, Breast cancer, Biomarkers, Tumor, Humans, METAANALYSIS, POLYMORPHISMS, Enzyme Assays, Phenylacetates, Aryldialkylphosphatase, Hydrolysis, Carcinoma, Ductal, Breast, Middle Aged, Survival Analysis, [SDV] Life Sciences [q-bio], Logistic Models, Oxidative stress, Paraoxonase, Female, Neoplasm Recurrence, Local, SERUM PARAOXONASE
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