β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Copyright policy )β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We show that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation. If beta-catenin is deleted after hair follicles have formed, hair is completely lost after the first hair cycle. Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate.
- University of Pennsylvania United States
- Max Delbrück Center for Molecular Medicine Germany
- Helmholtz Association of German Research Centres Germany
Keratinocytes, Mice, Knockout, Integrases, Biochemistry, Genetics and Molecular Biology(all), Stem Cells, Keratin-14, Cell Differentiation, Gene Expression Regulation, Enzymologic, Cytoskeletal Proteins, Mice, Mutagenesis, Insertional, Viral Proteins, Phenotype, Trans-Activators, Animals, Keratins, Cell Lineage, Hair Follicle, Gene Deletion, beta Catenin
Keratinocytes, Mice, Knockout, Integrases, Biochemistry, Genetics and Molecular Biology(all), Stem Cells, Keratin-14, Cell Differentiation, Gene Expression Regulation, Enzymologic, Cytoskeletal Proteins, Mice, Mutagenesis, Insertional, Viral Proteins, Phenotype, Trans-Activators, Animals, Keratins, Cell Lineage, Hair Follicle, Gene Deletion, beta Catenin
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