Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors
Copyright policy )Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors
A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC(50)=1.1nM) and antitumor activity in human cancer xenografts in mice.
Chemistry, Pharmaceutical, Antineoplastic Agents, Quinolones, Crystallography, X-Ray, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Design, Animals, Farnesyltranstransferase, Humans, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Neoplasm Transplantation, Benzofurans
Chemistry, Pharmaceutical, Antineoplastic Agents, Quinolones, Crystallography, X-Ray, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Design, Animals, Farnesyltranstransferase, Humans, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Neoplasm Transplantation, Benzofurans
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).43 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!